Non-modifiable risk factors include gender, age, and familial history. The onset of disease occurs earlier in men. Men between 35 and 44 years old have a risk that is three times higher than women of the same age. The risk of CVD increases for women older than 55 and coincides with menopause. This is because estrogen decreases during menopause triggering an increase in triglycerides, LDL (i.e., bad) cholesterol, and total cholesterol. In contrast, the good cholesterol known as HDL decreases with menopause.
Additionally, a family history of sudden death or a myocardial infarction (MI) in a first-degree relative is considered a risk factor if the event occurred in a male relative before 55 years old, or in a female relative before 65 years old.